Across TCGA cell cohorts, SIX6 mutation is significantly associated with the RNA expression of many other genes, with 3 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SIX6-associated genes across cancer lineages are OR14C36, IQCF3, and OR11H2. Each is linked with SIX6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX6-to-partner and partner-to-SIX6 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX6→partner) and Y-score (partner→SIX6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR14C36 →	+0.010	+4.266	<.001	.004	3	1
LUNG_NSCLC_LUAD	IQCF3 →	+0.034	+4.228	<.001	<.001	3	1
LUNG_NSCLC_LUAD	OR11H2 →	+0.012	+3.481	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 3 strongest of 3 associations by consensus.

Exploration

SIX6 survival (RNA) · tumor vs normal (RNA) · all SIX6 data types