SIX4

Across TCGA patient cohorts, SIX4 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,260 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SIX4-associated proteins across cancer lineages are IRF2BPL, TRMT5, and UHRF1. Each is linked with SIX4 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIX4-to-partner and partner-to-SIX4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIX4 versus IRF2BPL in LUAD, with a Pearson correlation of 0.49.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX4→partner) and Y-score (partner→SIX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	IRF2BPL →	+0.338	+0.555	<.001	<.001	3	6
LSCC	TRMT5 →	+0.579	+1.024	<.001	<.001	3	6
LSCC	UHRF1 →	+0.582	+0.848	.001	<.001	3	5
UCEC	FOXA1_S331 →	+1.561	+0.594	<.001	.002	3	5
LSCC	IPO9 →	+0.288	+0.633	.003	.009	3	5
BRCA	WEE1_S150 →	+0.751	+0.700	.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,260 associations by consensus.

SIX4 vs IRF2BPL — LUAD

Explore this scatter interactively →