SIX4

Across TCGA cell cohorts, SIX4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,937 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIX4-associated GO terms across cancer lineages are Fungiform papilla development, Fungiform papilla morphogenesis, and Olfactory placode formation. Each is linked with SIX4 in more than 17 cancer types. Because this analysis shows association rather than direction, both SIX4-to-partner and partner-to-SIX4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Fungiform papilla development grouped by SIX4-low versus SIX4-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX4→partner) and Y-score (partner→SIX4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Fungiform papilla development →	-0.240	-1.965	<.001	<.001	3	18
LARGE_INTESTINE	Fungiform papilla morphogenesis →	-0.240	-1.965	<.001	<.001	3	18
BLOOD_Myeloma	Olfactory placode formation →	+1.363	+2.039	<.001	<.001	3	17
BLOOD_Myeloma	Olfactory placode development →	+1.363	+2.039	<.001	<.001	3	17
BLOOD_Myeloma	Olfactory placode morphogenesis →	+1.363	+2.039	<.001	<.001	3	17
KIDNEY	Ectodermal placode formation →	-0.151	-1.323	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,937 associations by consensus.

Fungiform papilla development by SIX4 expression — LARGE_INTESTINE

Explore this box plot interactively →