SIX3

Across TCGA patient cohorts, SIX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,005 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible SIX3-associated GO terms across cancer lineages are Regulation of protein serine/threonine kinase activity, Regulation of microtubule cytoskeleton organization, and Regulation of microtubule polymerization or depolymerization. Each is linked with SIX3 in more than 17 cancer types. Because this analysis shows association rather than direction, both SIX3-to-partner and partner-to-SIX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein serine/threonine kinase activity grouped by SIX3-low versus SIX3-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX3→partner) and Y-score (partner→SIX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Regulation of protein serine/threonine kinase activity →	+0.045	+0.409	<.001	<.001	3	18
STAD	Regulation of microtubule cytoskeleton organization →	+0.065	+0.691	<.001	<.001	3	16
STAD	Regulation of microtubule polymerization or depolymerization →	+0.049	+0.496	<.001	<.001	3	16
STAD	Microtubule polymerization →	+0.055	+0.544	<.001	<.001	3	16
STAD	Positive regulation of organelle assembly →	+0.057	+0.437	<.001	<.001	3	16
STAD	Nuclear membrane reassembly →	+0.063	+0.450	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,005 associations by consensus.

Regulation of protein serine/threonine kinase activity by SIX3 expression — STAD

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