SIX3

Across TCGA patient cohorts, SIX3 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIX3-associated genes across cancer lineages are FoxM1, TFRC, and ATM. Each is linked with SIX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX3-to-partner and partner-to-SIX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SIX3-low versus SIX3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX3→partner) and Y-score (partner→SIX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.316	+1.906	.002	.016	3	2
UCEC	TFRC →	+0.676	+2.415	.001	.003	3	2
UCEC	ATM →	-0.529	-3.308	.003	.009	3	2
UCEC	Cyclin-B1 →	+0.675	+3.321	.002	.009	3	2
UCEC	eEF2 →	+0.392	+2.415	.006	.003	3	1
UCEC	EGFR_pY1068 →	-0.344	-2.415	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

FoxM1 by SIX3 expression — UCEC

Explore this box plot interactively →