SIX3

Across TCGA cell cohorts, SIX3 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,354 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SIX3-associated GO terms across cancer lineages are Regulation of neural retina development, Heterochromatin organization, and Neuroblast differentiation. Each is linked with SIX3 in more than 10 cancer types. Because this analysis shows association rather than direction, both SIX3-to-partner and partner-to-SIX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of neural retina development grouped by SIX3-low versus SIX3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX3→partner) and Y-score (partner→SIX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of neural retina development →	+1.074	+2.417	.001	<.001	3	11
PANCREAS	Heterochromatin organization →	+0.045	+0.770	<.001	.001	3	7
LUNG_SCLC	Neuroblast differentiation →	+1.564	+3.013	<.001	<.001	3	6
PANCREAS	Heart contraction →	-0.089	-0.545	.003	.006	2	7
LUNG_SCLC	Regulation of translational elongation →	+0.083	+1.360	.002	.004	3	6
BONE	5S class rRNA transcription by RNA polymerase III →	+0.158	+1.545	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,354 associations by consensus.

Regulation of neural retina development by SIX3 expression — BONE

Explore this box plot interactively →