SIX3

Across TCGA cell cohorts, SIX3 mutation is significantly associated with the RNA expression of many other genes, with 365 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIX3-associated genes across cancer lineages are OR4X2, KRTAP17-1, and KRT33A. Each is linked with SIX3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIX3-to-partner and partner-to-SIX3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR4X2 grouped by SIX3-low versus SIX3-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIX3→partner) and Y-score (partner→SIX3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	OR4X2 →	+0.032	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRTAP17-1 →	+0.016	+5.369	<.001	.004	3	1
SOFT_TISSUE	KRT33A →	+0.058	+4.930	<.001	.008	3	1
LARGE_INTESTINE	TNRC6B →	+0.810	+3.364	<.001	.002	3	1
LARGE_INTESTINE	PCK2 →	+0.991	+3.364	.004	.002	3	1
LARGE_INTESTINE	OCIAD1 →	+0.407	+3.125	.008	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 365 associations by consensus.

OR4X2 by SIX3 expression — SOFT_TISSUE

Explore this box plot interactively →