SIX1

Across TCGA pan-cancer cohorts, SIX1 mass-spec protein is linked to patient survival in 2 of 34 cancer types, making it a survival-associated SIX1 data layer compared with 25 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SIX1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated SIX1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC and LUAD are the cancer types where SIX1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	OS	Tertile	All	0.907	0.668	.007	11	view →
LUAD	DFS	Median	All	0.468	1.000	.013	2	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

SIX1–LSCC (OS)

Open the LSCC breakdown →