Across TCGA patient cohorts, SIVA1 protein abundance is significantly associated with the RNA expression of many other genes, with 6,825 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIVA1-associated genes across cancer lineages are MTHFD1, WDR25, and C17orf75. Each is linked with SIVA1 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIVA1-to-partner and partner-to-SIVA1 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIVA1→partner) and Y-score (partner→SIVA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MTHFD1 →	+1.111	+0.400	.001	.005	3	6
COAD	WDR25 →	+1.135	+0.565	.008	.007	3	6
HNSC	C17orf75 →	+0.717	+0.681	.001	<.001	3	5
BRCA	NEK9 →	+0.812	+0.848	<.001	<.001	3	5
LSCC	ACYP1 →	+0.878	+0.812	<.001	<.001	3	5
HNSC	IFT43 →	+0.505	+0.732	.003	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,825 associations by consensus.

Exploration

SIVA1 survival (RNA) · tumor vs normal (RNA) · all SIVA1 data types