Across TCGA patient cohorts, SIVA1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIVA1-associated genes across cancer lineages are ACC_pS79, Bcl-2, and MEK1_p_S217_S221. Each is linked with SIVA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIVA1-to-partner and partner-to-SIVA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIVA1→partner) and Y-score (partner→SIVA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACC_pS79 →	+0.374	+2.817	.049	.036	3	1
UCEC	Bcl-2 →	-0.517	-2.980	.006	.036	3	1
UCEC	MEK1_p_S217_S221 →	+0.580	+3.169	<.001	.020	2	1
UCEC	PKC-a_pS657 →	-0.493	-2.990	.018	.036	2	1
UCEC	TFRC →	+0.850	+3.169	.003	.020	1	1
UCEC	BRCA2 →	-0.159	-3.162	.022	.019	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

SIVA1 survival (RNA) · tumor vs normal (RNA) · all SIVA1 data types