SIRT6

Across TCGA patient cohorts, SIRT6 RNA expression is significantly associated with the mutation status of many other genes, with 11,776 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRT6-associated genes across cancer lineages are FLG, MUC5B, and MUC16. Each is linked with SIRT6 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIRT6-to-partner and partner-to-SIRT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FLG grouped by SIRT6-low versus SIRT6-high in UCEC.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT6→partner) and Y-score (partner→SIRT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FLG →	+1.247	+0.348	<.001	<.001	3	6
STAD	MUC5B →	+1.743	+0.259	.009	.008	3	5
UCEC	MUC16 →	+1.253	+0.337	<.001	<.001	3	5
UCEC	KRAS →	+1.258	+0.285	<.001	<.001	3	4
LUAD	PCDHA2 →	+1.925	+0.322	.005	.004	3	4
STAD	CACNA1E →	+2.650	+0.330	.004	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,776 associations by consensus.

FLG by SIRT6 expression — UCEC

Explore this box plot interactively →