SIRT6

Across TCGA pan-cancer cohorts, SIRT6 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of SIRT6’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where SIRT6 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SIRT6 is over-expressed in tumor, although a few such as COAD and KICH show the opposite, repressed pattern.

HNSC, KIRP, and KIRC are the cancer types where SIRT6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIRT6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.007	<.001	12	view →
KIRP	Male	II,III,IV	+0.851	<.001	11	view →
KIRC	Female	All	+0.525	<.001	11	view →
LIHC	Female	II,III,IV	+1.227	<.001	9	view →
STAD	All	II,III,IV	+0.971	<.001	8	view →
BLCA	All	All	+0.691	.001	7	view →
UCEC	All	All	+0.546	<.001	6	view →
BRCA	All	All	+0.491	<.001	6	view →
COAD	All	All	−0.473	<.001	6	view →
LUSC	All	II,III,IV	+0.470	<.001	6	view →
LUAD	Female	II,III,IV	+0.448	.001	6	view →
THCA	Female	All	+0.328	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

SIRT6–HNSC

Open the HNSC breakdown →