SIRT6

Across TCGA patient cohorts, SIRT6 protein abundance is significantly associated with the RNA expression of many other genes, with 5,461 significant associations in total. GBM shows the largest number of these associations.

The most reproducible SIRT6-associated genes across cancer lineages are SGTA, HAUS8, and POLQ. Each is linked with SIRT6 in more than 4 cancer types. Because this analysis shows association rather than direction, both SIRT6-to-partner and partner-to-SIRT6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIRT6 versus SGTA in HNSC, with a Pearson correlation of 0.17.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT6→partner) and Y-score (partner→SIRT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SGTA →	+0.662	+0.280	.008	.009	3	5
LSCC	HAUS8 →	+0.560	+0.256	<.001	<.001	3	4
HNSC	POLQ →	+0.740	+0.271	<.001	.001	3	4
HNSC	YJU2 →	+0.973	+0.286	.004	.006	3	4
HNSC	DDX39A →	+0.671	+0.250	.006	.007	3	4
HNSC	GTF2F1 →	+0.797	+0.205	.005	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,461 associations by consensus.

SIRT6 vs SGTA — HNSC

Explore this scatter interactively →