SIRT6

Across TCGA patient cohorts, SIRT6 mutation is significantly associated with the immune_cell of many other genes, with 4 significant associations in total. LUSC shows the largest number of these associations.

The most reproducible SIRT6-associated genes across cancer lineages are MPP, CD4+ Tcm, and lymphatic Endothelial cells. Each is linked with SIRT6 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT6-to-partner and partner-to-SIRT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MPP grouped by SIRT6-low versus SIRT6-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT6→partner) and Y-score (partner→SIRT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	MPP →	+0.017	+4.694	<.001	.014	3	1
LUSC	CD4+ Tcm →	+0.009	+5.593	.004	.030	3	1
UCEC	lymphatic Endothelial cells →	-0.025	-2.968	.046	.036	3	1
UCEC	HSC →	+0.129	+3.332	.024	.005	1	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

MPP by SIRT6 expression — LUSC

Explore this box plot interactively →