SIRT6

Across TCGA cell cohorts, SIRT6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,905 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SIRT6-associated GO terms across cancer lineages are Positive regulation of protein localization to chromatin, Negative regulation of protein localization to chromatin, and Energy coupled proton transmembrane transport, against electrochemical gradient. Each is linked with SIRT6 in more than 17 cancer types. Because this analysis shows association rather than direction, both SIRT6-to-partner and partner-to-SIRT6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of protein localization to chromatin grouped by SIRT6-low versus SIRT6-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT6→partner) and Y-score (partner→SIRT6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of protein localization to chromatin →	+0.159	+1.241	<.001	<.001	3	18
LIVER	Negative regulation of protein localization to chromatin →	+0.155	+1.170	.002	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.083	+0.789	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Electron transport coupled proton transport →	+0.083	+0.789	<.001	<.001	3	17
BONE	Cytoplasm protein quality control →	+0.162	+0.709	<.001	<.001	3	16
BONE	Regulation of protein localization to chromatin →	+0.158	+0.696	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,905 associations by consensus.

Positive regulation of protein localization to chromatin by SIRT6 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →