SIRT5

Across TCGA patient cohorts, SIRT5 RNA expression is significantly associated with the RNA expression of many other genes, with 20,086 significant associations in total. ACC shows the largest number of these associations.

The most reproducible SIRT5-associated genes across cancer lineages are SLC35B3, FAM8A1, and CCDC121. Each is linked with SIRT5 in more than 31 cancer types. Because this analysis shows association rather than direction, both SIRT5-to-partner and partner-to-SIRT5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIRT5 versus SLC35B3 in UVM, with a Pearson correlation of 0.86.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT5→partner) and Y-score (partner→SIRT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UVM	SLC35B3 →	+1.505	+1.053	<.001	<.001	3	32
UVM	FAM8A1 →	+1.518	+0.990	<.001	<.001	3	32
UVM	CCDC121 →	+1.067	+0.958	<.001	<.001	3	32
UVM	ZNF322 →	+1.122	+0.994	<.001	<.001	3	32
ACC	RXRB →	+0.788	+0.805	<.001	<.001	3	32
UVM	RANBP9 →	+1.415	+1.023	<.001	<.001	3	32

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,086 associations by consensus.

SIRT5 vs SLC35B3 — UVM

Explore this scatter interactively →