SIRT5

Across TCGA patient cohorts, SIRT5 RNA expression is significantly associated with the protein abundance of many other proteins, with 18,105 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIRT5-associated proteins across cancer lineages are WRNIP1, NUP153, and PRPF4B. Each is linked with SIRT5 in more than 7 cancer types. Because this analysis shows association rather than direction, both SIRT5-to-partner and partner-to-SIRT5 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIRT5 versus WRNIP1 in OV, with a Pearson correlation of 0.50.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT5→partner) and Y-score (partner→SIRT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	WRNIP1 →	+0.652	+0.823	<.001	<.001	3	8
OV	NUP153 →	+0.417	+1.121	<.001	<.001	3	7
OV	PRPF4B →	+0.442	+0.806	<.001	<.001	2	7
LSCC	NELFE →	+0.273	+0.639	<.001	<.001	3	5
BRCA	PHF3 →	+0.235	+0.427	.001	<.001	3	5
BRCA	PPIL1 →	+0.220	+0.380	.001	.004	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,105 associations by consensus.

SIRT5 vs WRNIP1 — OV

Explore this scatter interactively →