SIRT5

Across TCGA patient cohorts, SIRT5 mutation is significantly associated with the RNA expression of many other genes, with 2,656 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRT5-associated genes across cancer lineages are RNA5SP412, FARP1, and AP3S2. Each is linked with SIRT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT5-to-partner and partner-to-SIRT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP412 grouped by SIRT5-low versus SIRT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT5→partner) and Y-score (partner→SIRT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP412 →	+0.532	+2.060	<.001	.002	3	2
UCEC	FARP1 →	+0.539	+1.858	<.001	.005	3	2
UCEC	AP3S2 →	+0.310	+2.633	.003	.005	3	2
UCEC	CHAF1B →	+0.592	+2.431	.001	.001	3	2
UCEC	LSS →	+0.530	+2.290	<.001	.001	3	2
UCEC	IDH3A →	+0.587	+2.280	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,656 associations by consensus.

RNA5SP412 by SIRT5 expression — UCEC

Explore this box plot interactively →