SIRT5

Across TCGA patient cohorts, SIRT5 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRT5-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and eIF4G. Each is linked with SIRT5 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT5-to-partner and partner-to-SIRT5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by SIRT5-low versus SIRT5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT5→partner) and Y-score (partner→SIRT5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.116	-1.893	.004	.016	3	1
UCEC	EGFR_pY1068 →	-0.313	-3.087	.001	<.001	3	1
UCEC	eIF4G →	+0.312	+1.906	.012	.016	3	1
UCEC	A-Raf_pS299 →	-0.200	-3.700	<.001	.001	3	1
UCEC	FoxM1 →	+0.308	+2.415	.003	.003	3	1
UCEC	GATA6 →	-0.151	-1.800	.017	.027	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

14-3-3_beta by SIRT5 expression — UCEC

Explore this box plot interactively →