SIRT4

Across TCGA pan-cancer cohorts, SIRT4 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SIRT4 data layer compared with 23 for mass-spec protein.

The strongest signal is observed in esophageal carcinoma (ESCA), where higher SIRT4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated SIRT4 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

ESCA, UCEC, and SKCM are the cancer types where SIRT4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ESCA	OS	Median	II,III,IV	0.164	0.702	.001	33	view →
UCEC	DFS	Median	III,IV	1.000	0.536	.029	16	view →
SKCM	DFS	Median	II,III,IV	1.000	0.561	.036	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SIRT4–ESCA (OS)

Open the ESCA breakdown →