SIRT4

Across TCGA pan-cancer cohorts, SIRT4 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of SIRT4’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SIRT4 RNA is repressed in tumor relative to normal tissue. In most cancer types SIRT4 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where SIRT4 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIRT4 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	−0.791	<.001	10	view →
KIRC	All	II,III,IV	−0.434	<.001	10	view →
LIHC	Male	All	+0.893	<.001	9	view →
UCEC	All	All	−0.453	.002	6	view →
STAD	All	All	−0.428	.001	6	view →
KICH	All	All	−0.669	<.001	5	view →
READ	All	II,III,IV	−0.597	.030	5	view →
COAD	All	All	−0.409	<.001	4	view →
BRCA	All	All	−0.254	<.001	4	view →
LUSC	Female	III,IV	−0.474	.021	2	view →
LUAD	All	II,III,IV	−0.283	.028	2	view →
HNSC	Male	All	−0.326	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

SIRT4–THCA

Open the THCA breakdown →