SIRT4

Across TCGA patient cohorts, SIRT4 protein abundance is significantly associated with the RNA expression of many other genes, with 302 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SIRT4-associated genes across cancer lineages are FAH, ARMC1, and EFNB3. Each is linked with SIRT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT4-to-partner and partner-to-SIRT4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIRT4 versus FAH in CCRCC, with a Pearson correlation of -0.70.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT4→partner) and Y-score (partner→SIRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	FAH →	-1.007	-0.952	.006	<.001	3	1
CCRCC	ARMC1 →	-0.448	-1.187	.002	<.001	3	1
CCRCC	EFNB3 →	+0.627	+1.218	.006	<.001	3	1
CCRCC	WFS1 →	+0.922	+1.079	.002	.001	3	1
CCRCC	MGP →	+2.260	+1.302	.001	.002	3	1
CCRCC	MCM9 →	+0.714	+1.218	.003	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 302 associations by consensus.

SIRT4 vs FAH — CCRCC

Explore this scatter interactively →