SIRT4

Across TCGA patient cohorts, SIRT4 protein abundance is significantly associated with the protein abundance of many other proteins, with 433 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible SIRT4-associated proteins across cancer lineages are PTPRS, RNPC3_S108, and ASPN. Each is linked with SIRT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT4-to-partner and partner-to-SIRT4 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIRT4 versus PTPRS in CCRCC, with a Pearson correlation of 0.79.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT4→partner) and Y-score (partner→SIRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	PTPRS →	+0.930	+1.276	.003	<.001	3	1
CCRCC	RNPC3_S108 →	-0.571	-1.187	<.001	<.001	3	1
CCRCC	ASPN →	+1.539	+1.218	<.001	<.001	3	1
CCRCC	CCDC86 →	-0.776	-1.546	.001	.003	3	1
CCRCC	ADH1C →	+1.265	+1.414	.002	<.001	3	1
CCRCC	CHL1 →	+0.767	+1.384	.007	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 433 associations by consensus.

SIRT4 vs PTPRS — CCRCC

Explore this scatter interactively →