SIRT4

Across TCGA patient cohorts, SIRT4 mutation is significantly associated with the RNA expression of many other genes, with 1,644 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRT4-associated genes across cancer lineages are MTND5P5, RNU6-1103P, and USP9YP5. Each is linked with SIRT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT4-to-partner and partner-to-SIRT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MTND5P5 grouped by SIRT4-low versus SIRT4-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT4→partner) and Y-score (partner→SIRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MTND5P5 →	+0.109	+6.144	<.001	.001	3	2
BRCA	RNU6-1103P →	+0.269	+9.057	<.001	.003	3	2
BRCA	USP9YP5 →	+0.084	+8.471	<.001	.005	3	2
LUSC	SCARNA21B →	+0.367	+4.849	<.001	.002	3	2
COAD	RNU6-13P →	+0.946	+4.893	<.001	.005	3	2
COAD	EIF4E2P1 →	+1.132	+5.484	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,644 associations by consensus.

MTND5P5 by SIRT4 expression — CESC

Explore this box plot interactively →