SIRT4

Across TCGA patient cohorts, SIRT4 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRT4-associated genes across cancer lineages are FoxM1, JNK2, and Ku80. Each is linked with SIRT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT4-to-partner and partner-to-SIRT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by SIRT4-low versus SIRT4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT4→partner) and Y-score (partner→SIRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.293	+3.459	.024	.005	3	1
UCEC	JNK2 →	+0.442	+2.321	<.001	.035	3	1
UCEC	Ku80 →	+0.328	+3.472	.005	.002	3	1
UCEC	MEK1 →	+0.578	+3.459	.001	.005	3	1
UCEC	Notch1 →	+0.193	+2.321	.006	.035	3	1
UCEC	PCNA →	+0.323	+3.459	.002	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

FoxM1 by SIRT4 expression — UCEC

Explore this box plot interactively →