SIRT4

Across TCGA cell cohorts, SIRT4 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,691 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SIRT4-associated GO terms across cancer lineages are Negative regulation of protein localization to mitochondrion, RNA splicing, via transesterification reactions, and Autophagosome organization. Each is linked with SIRT4 in more than 12 cancer types. Because this analysis shows association rather than direction, both SIRT4-to-partner and partner-to-SIRT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of protein localization to mitochondrion grouped by SIRT4-low versus SIRT4-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT4→partner) and Y-score (partner→SIRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Negative regulation of protein localization to mitochondrion →	-0.165	-0.869	<.001	<.001	3	13
OVARY	RNA splicing, via transesterification reactions →	+0.069	+0.791	<.001	.001	3	12
STOMACH	Autophagosome organization →	+0.068	+0.764	<.001	.002	3	11
LARGE_INTESTINE	Peptidyl-lysine deacetylation →	-0.142	-0.530	<.001	.001	3	11
UPPER_AERODIGESTIVE_TRACT	Golgi vesicle transport →	+0.051	+0.364	<.001	.002	3	11
UPPER_AERODIGESTIVE_TRACT	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile →	+0.071	+0.537	.004	.004	2	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,691 associations by consensus.

Negative regulation of protein localization to mitochondrion by SIRT4 expression — SOFT_TISSUE

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