SIRT4

Across TCGA cell cohorts, SIRT4 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIRT4-associated genes across cancer lineages are IL2, MTRNR2L10, and MAGEB4. Each is linked with SIRT4 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT4-to-partner and partner-to-SIRT4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL2 grouped by SIRT4-low versus SIRT4-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT4→partner) and Y-score (partner→SIRT4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	IL2 →	+0.028	+5.196	<.001	.005	3	1
OVARY	MTRNR2L10 →	+0.006	+5.196	<.001	.005	3	1
LARGE_INTESTINE	MAGEB4 →	+0.016	+4.415	<.001	<.001	3	1
LARGE_INTESTINE	BPY2 →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2B →	+0.015	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPY2C →	+0.015	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

IL2 by SIRT4 expression — OVARY

Explore this box plot interactively →