SIRT3

Across TCGA patient cohorts, SIRT3 RNA expression is significantly associated with the protein abundance of many other proteins, with 12,790 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible SIRT3-associated proteins across cancer lineages are TOM1L1, RIC8A, and STK10. Each is linked with SIRT3 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIRT3-to-partner and partner-to-SIRT3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIRT3 versus TOM1L1 in BRCA, with a Pearson correlation of 0.46.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT3→partner) and Y-score (partner→SIRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TOM1L1 →	+0.539	+0.498	<.001	<.001	3	5
GBM	RIC8A →	+0.226	+0.339	.001	.001	2	6
GBM	STK10 →	-0.311	-0.289	.001	.002	3	5
GBM	BIN2 →	-0.459	-0.232	.001	.009	3	5
GBM	DOK3 →	-0.454	-0.335	<.001	<.001	3	5
BRCA	ASCC3 →	-0.307	-0.710	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,790 associations by consensus.

SIRT3 vs TOM1L1 — BRCA

Explore this scatter interactively →