SIRT3

Across TCGA pan-cancer cohorts, SIRT3 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SIRT3 data layer compared with 5 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in uveal melanoma (UVM), where higher SIRT3 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SIRT3 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

UVM, KIRP, and KIRC are the cancer types where SIRT3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	DFS	Median	All	0.930	0.538	<.001	102	view →
KIRP	DFS	Tertile	All	0.928	0.496	.001	84	view →
KIRC	OS	Median	All	0.713	0.545	<.001	67	view →
KICH	OS	Median	All	0.649	1.000	.001	62	view →
BRCA	OS	Tertile	All	0.959	0.896	<.001	56	view →
ACC	DFS	Tertile	All	0.258	0.770	<.001	36	view →
LUSC	DFS	Median	III,IV	0.423	0.674	.008	25	view →
CHOL	DFS	Tertile	All	0.837	0.082	.002	18	view →
READ	DFS	Quartile	All	0.892	0.565	.022	14	view →
SKCM	DFS	Median	All	0.663	0.578	.014	12	view →
MESO	OS	Quartile	All	0.566	0.268	.002	9	view →
HNSC	OS	Quartile	III,IV	0.269	0.556	.014	7	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SIRT3–UVM (DFS)

Open the UVM breakdown →