SIRT3

Across TCGA patient cohorts, SIRT3 mutation is significantly associated with the RNA expression of many other genes, with 868 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRT3-associated genes across cancer lineages are MAGI2-AS2, MORC1-AS1, and C2orf69P4. Each is linked with SIRT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT3-to-partner and partner-to-SIRT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGI2-AS2 grouped by SIRT3-low versus SIRT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT3→partner) and Y-score (partner→SIRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MAGI2-AS2 →	+0.131	+3.598	<.001	.002	3	2
COAD	MORC1-AS1 →	+0.142	+7.741	.001	.009	3	2
COAD	C2orf69P4 →	+0.149	+7.741	<.001	.009	3	2
COAD	MIR3689B →	+0.273	+7.741	<.001	.009	3	2
LUAD	RNU6-952P →	+0.369	+5.631	<.001	.004	3	2
LUAD	MIR4736 →	+0.993	+6.584	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 868 associations by consensus.

MAGI2-AS2 by SIRT3 expression — UCEC

Explore this box plot interactively →