SIRT3

Across TCGA patient cohorts, SIRT3 mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRT3-associated genes across cancer lineages are Ku80, MEK1, and PCNA. Each is linked with SIRT3 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT3-to-partner and partner-to-SIRT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by SIRT3-low versus SIRT3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT3→partner) and Y-score (partner→SIRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.356	+3.013	.009	.019	3	1
UCEC	MEK1 →	+0.464	+3.000	.028	.036	3	1
UCEC	PCNA →	+0.338	+3.000	.006	.037	2	1
UCEC	STAT3_pY705 →	-0.498	-3.000	.001	.037	2	1
UCEC	mTOR_pS2448 →	-0.253	-3.000	.003	.037	1	1
UCEC	p38-MAPK_pT180_Y182 →	-0.597	-2.986	.021	.037	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Ku80 by SIRT3 expression — UCEC

Explore this box plot interactively →