SIRT3

Across TCGA cell cohorts, SIRT3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,769 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SIRT3-associated GO terms across cancer lineages are Peptidyl-lysine deacetylation, Cellular detoxification of methylglyoxal, and Cilium or flagellum-dependent cell motility. Each is linked with SIRT3 in more than 19 cancer types. Because this analysis shows association rather than direction, both SIRT3-to-partner and partner-to-SIRT3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Peptidyl-lysine deacetylation grouped by SIRT3-low versus SIRT3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT3→partner) and Y-score (partner→SIRT3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Peptidyl-lysine deacetylation →	+0.232	+0.804	<.001	.002	3	20
OESOPHAGUS	Cellular detoxification of methylglyoxal →	+0.161	+1.043	<.001	<.001	3	17
OESOPHAGUS	Cilium or flagellum-dependent cell motility →	-0.130	-1.551	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.138	+1.035	<.001	<.001	3	17
OESOPHAGUS	Response to methylglyoxal →	+0.161	+1.043	<.001	<.001	3	17
OESOPHAGUS	Cilium-dependent cell motility →	-0.130	-1.551	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,769 associations by consensus.

Peptidyl-lysine deacetylation by SIRT3 expression — LIVER

Explore this box plot interactively →