SIRT2

Across TCGA patient cohorts, SIRT2 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRT2-associated genes across cancer lineages are p38-MAPK_pT180_Y182, EGFR_pY1068, and EGFR. Each is linked with SIRT2 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT2-to-partner and partner-to-SIRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by SIRT2-low versus SIRT2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT2→partner) and Y-score (partner→SIRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.435	-2.222	.016	.010	3	2
UCEC	EGFR_pY1068 →	-0.256	-2.415	.011	.003	3	1
UCEC	EGFR →	-0.180	-2.321	.005	.034	3	1
UCEC	A-Raf_pS299 →	-0.097	-3.169	.044	.019	3	1
UCEC	ERK2 →	+0.174	+3.321	.025	.009	3	1
UCEC	FoxM1 →	+0.220	+1.906	.034	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

p38-MAPK_pT180_Y182 by SIRT2 expression — UCEC

Explore this box plot interactively →