SIRT2

Across TCGA pan-cancer cohorts, SIRT2 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SIRT2 data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher SIRT2 RNA is associated with better overall survival. In most high-consensus cancer types, elevated SIRT2 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and UCS are the cancer types where SIRT2 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	IV	0.460	0.217	<.001	73	view →
KIRC	DFS	Tertile	All	0.770	0.481	<.001	70	view →
UCS	DFS	Median	III,IV	0.492	0.143	.005	36	view →
LAML	DFS	Tertile	All	0.391	0.651	.003	28	view →
LUAD	DFS	Median	II,III,IV	0.752	0.604	<.001	23	view →
SKCM	OS	Tertile	All	0.820	0.957	.002	22	view →
ESCA	OS	Median	All	1.000	0.670	.026	21	view →
OV	OS	Median	III,IV	0.790	0.879	.009	20	view →
COAD	OS	Quartile	IV	0.875	0.401	.006	18	view →
PAAD	DFS	Quartile	All	0.525	0.196	.002	16	view →
MESO	OS	Quartile	III,IV	0.424	0.671	.021	16	view →
UCEC	OS	Quartile	All	0.790	0.882	.019	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SIRT2–HNSC (OS)

Open the HNSC breakdown →