SIRT2

Across TCGA cell cohorts, SIRT2 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,820 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible SIRT2-associated GO terms across cancer lineages are Tubulin deacetylation, Negative regulation of oligodendrocyte progenitor proliferation, and Regulation of oocyte maturation. Each is linked with SIRT2 in more than 19 cancer types. Because this analysis shows association rather than direction, both SIRT2-to-partner and partner-to-SIRT2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Tubulin deacetylation grouped by SIRT2-low versus SIRT2-high in OESOPHAGUS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT2→partner) and Y-score (partner→SIRT2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	Tubulin deacetylation →	+0.196	+1.275	<.001	<.001	3	20
LUNG_NSCLC_LUSC	Negative regulation of oligodendrocyte progenitor proliferation →	+0.972	+1.818	.005	<.001	3	19
OVARY	Regulation of oocyte maturation →	+0.379	+1.286	<.001	<.001	3	16
CNS	Response to caloric restriction →	+0.197	+0.996	<.001	<.001	3	16
OESOPHAGUS	Positive regulation of cell maturation →	+0.349	+1.377	<.001	<.001	3	14
SOFT_TISSUE	Positive regulation of attachment of spindle microtubules to kinetochore →	+0.162	+1.182	<.001	.004	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,820 associations by consensus.

Tubulin deacetylation by SIRT2 expression — OESOPHAGUS

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