SIRT1

Across TCGA patient cohorts, SIRT1 mutation is significantly associated with the RNA expression of many other genes, with 3,022 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIRT1-associated genes across cancer lineages are RN7SL392P, UBTFL3, and RNU1-17P. Each is linked with SIRT1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SIRT1-to-partner and partner-to-SIRT1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL392P grouped by SIRT1-low versus SIRT1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIRT1→partner) and Y-score (partner→SIRT1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	RN7SL392P →	+0.068	+4.469	<.001	.006	3	2
HNSC	UBTFL3 →	+0.079	+7.954	<.001	.008	3	2
UCEC	RNU1-17P →	+0.133	+1.988	.002	.002	3	2
UCEC	RN7SKP214 →	+0.165	+1.460	<.001	.006	3	2
UCEC	BOLA3P3 →	+0.235	+1.547	.002	.001	3	2
UCEC	PSAT1P4 →	+0.116	+1.733	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,022 associations by consensus.

RN7SL392P by SIRT1 expression — SKCM

Explore this box plot interactively →