SIRPG-AS1

Across TCGA pan-cancer cohorts, SIRPG-AS1 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated SIRPG-AS1 data layer.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher SIRPG-AS1 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated SIRPG-AS1 expression acts as an unfavorable survival marker, although some lineages such as BLCA and SKCM show a favorable association.

BLCA, UVM, and SKCM are the cancer types where SIRPG-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	DFS	Quartile	III,IV	0.408	0.153	<.001	129	view →
UVM	OS	Tertile	All	0.287	0.734	<.001	120	view →
SKCM	OS	Median	All	0.915	0.828	<.001	112	view →
HNSC	OS	Tertile	All	0.441	0.294	.001	89	view →
BRCA	DFS	Median	III,IV	0.868	0.717	<.001	75	view →
LUAD	DFS	Median	II,III,IV	0.709	0.410	<.001	60	view →
KICH	DFS	Tertile	II,III,IV	0.521	0.950	.006	36	view →
KIRP	DFS	Quartile	All	0.726	0.888	.003	35	view →
KIRC	OS	Median	All	0.574	0.727	.007	24	view →
ACC	DFS	Tertile	III,IV	0.055	0.398	.011	24	view →
LIHC	DFS	Median	III,IV	0.408	0.176	.006	24	view →
READ	OS	Median	II,III,IV	0.807	0.422	.002	23	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

SIRPG-AS1–BLCA (DFS)

Open the BLCA breakdown →