SIRPG-AS1

Across TCGA pan-cancer cohorts, SIRPG-AS1 RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of SIRPG-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where SIRPG-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SIRPG-AS1 is over-expressed in tumor, although a few such as UCEC and THCA show the opposite, repressed pattern.

KIRC, HNSC, and BRCA are the cancer types where SIRPG-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIRPG-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.301	<.001	11	view →
HNSC	All	IV	+0.056	<.001	11	view →
BRCA	All	II,III,IV	+0.072	.015	4	view →
UCEC	All	All	−0.064	.013	4	view →
STAD	All	All	+0.228	.005	3	view →
LUAD	All	All	+0.182	.006	2	view →
THCA	All	All	−0.114	.012	2	view →
CHOL	All	All	+0.102	.029	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

SIRPG-AS1–KIRC

Open the KIRC breakdown →