SIPA1L3

Across TCGA cell cohorts, SIPA1L3 mutation is significantly associated with the RNA expression of many other genes, with 933 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIPA1L3-associated genes across cancer lineages are BLOC1S5, C4orf46, and SIRT1. Each is linked with SIPA1L3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIPA1L3-to-partner and partner-to-SIPA1L3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BLOC1S5 grouped by SIPA1L3-low versus SIPA1L3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1L3→partner) and Y-score (partner→SIPA1L3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BLOC1S5 →	+0.420	+2.850	.001	<.001	3	3
LARGE_INTESTINE	C4orf46 →	+0.605	+2.936	<.001	<.001	3	3
LARGE_INTESTINE	SIRT1 →	+0.593	+2.850	<.001	<.001	3	3
BLOOD_Leukemia	C4orf50 →	+0.109	+2.227	.004	.001	3	3
BLOOD_Leukemia	HIRIP3 →	+0.536	+3.321	.002	.005	3	3
SOFT_TISSUE	BECN2 →	+0.181	+3.865	<.001	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 933 associations by consensus.

BLOC1S5 by SIPA1L3 expression — LARGE_INTESTINE

Explore this box plot interactively →