Across TCGA patient cohorts, SIPA1 mutation is significantly associated with the RNA expression of many other genes, with 621 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIPA1-associated genes across cancer lineages are MTND6P17, IGHVIV-44-1, and MAGEB16. Each is linked with SIPA1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIPA1-to-partner and partner-to-SIPA1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIPA1→partner) and Y-score (partner→SIPA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MTND6P17 →	+0.044	+4.147	<.001	.008	3	3
CESC	IGHVIV-44-1 →	+0.150	+5.201	.005	.007	3	2
LGG	MAGEB16 →	+0.050	+5.093	<.001	.008	3	2
UCEC	FAM177A1 →	+0.400	+2.425	.002	.002	3	2
UCEC	CENPU →	+0.656	+2.447	.005	.001	3	2
LUAD	RNU6-1213P →	+0.508	+7.930	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 621 associations by consensus.

Exploration

SIPA1 survival (RNA) · tumor vs normal (RNA) · all SIPA1 data types