SINHCAF

Across TCGA patient cohorts, SINHCAF mutation is significantly associated with the RNA expression of many other genes, with 959 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SINHCAF-associated genes across cancer lineages are TRBV17, RNU6-1028P, and MIR4491. Each is linked with SINHCAF in more than 1 cancer types. Because this analysis shows association rather than direction, both SINHCAF-to-partner and partner-to-SINHCAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRBV17 grouped by SINHCAF-low versus SINHCAF-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SINHCAF→partner) and Y-score (partner→SINHCAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	TRBV17 →	+0.203	+5.721	<.001	.003	3	1
BRCA	RNU6-1028P →	+0.616	+6.268	<.001	.001	3	1
BRCA	MIR4491 →	+0.760	+5.721	<.001	.003	3	1
SKCM	RNU7-62P →	+0.383	+7.816	<.001	.008	3	1
BRCA	OR5T3 →	+0.041	+6.950	.005	<.001	3	1
BRCA	RNU6-363P →	+0.195	+8.057	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 959 associations by consensus.

TRBV17 by SINHCAF expression — BRCA

Explore this box plot interactively →