SINHCAF

Across TCGA pan-cancer cohorts, SINHCAF RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of SINHCAF’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where SINHCAF RNA is more highly expressed in tumor relative to normal tissue. In most cancer types SINHCAF is over-expressed in tumor, although a few such as KIRC and UCEC show the opposite, repressed pattern.

BLCA, KIRC, and COAD are the cancer types where SINHCAF tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SINHCAF RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	III,IV	+1.784	<.001	11	view →
KIRC	Male	III,IV	−0.775	<.001	10	view →
COAD	Male	All	+1.377	<.001	9	view →
LUAD	Male	All	+1.248	<.001	9	view →
HNSC	Male	All	+1.038	<.001	8	view →
STAD	Male	II,III,IV	+1.652	<.001	7	view →
READ	All	All	+0.983	<.001	7	view →
LUSC	Male	II,III,IV	+1.292	<.001	6	view →
LIHC	All	II,III,IV	+0.842	.002	6	view →
CHOL	Male	All	+3.614	<.001	5	view →
ESCA	All	All	+1.383	.001	5	view →
UCEC	All	IV	−1.849	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

SINHCAF–BLCA

Open the BLCA breakdown →