SINHCAF

Across TCGA patient cohorts, SINHCAF mutation is significantly associated with the immune_cell of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SINHCAF-associated genes across cancer lineages are mv Endothelial cells, Class-switched memory B-cells, and lymphatic Endothelial cells. Each is linked with SINHCAF in more than 1 cancer types. Because this analysis shows association rather than direction, both SINHCAF-to-partner and partner-to-SINHCAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mv Endothelial cells grouped by SINHCAF-low versus SINHCAF-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SINHCAF→partner) and Y-score (partner→SINHCAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mv Endothelial cells →	-0.027	-3.321	.010	.010	3	1
UCEC	Class-switched memory B-cells →	-0.060	-2.807	.016	.003	2	1
UCEC	lymphatic Endothelial cells →	-0.027	-3.660	.009	.001	2	1
UCEC	Plasma cells →	-0.019	-2.072	.041	.019	2	1
UCEC	Endothelial cells →	-0.046	-3.863	.006	<.001	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

mv Endothelial cells by SINHCAF expression — UCEC

Explore this box plot interactively →