SINHCAF

Across TCGA cell cohorts, SINHCAF mutation is significantly associated with the RNA expression of many other genes, with 2 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible SINHCAF-associated genes across cancer lineages are HMHB1 and CCL13. Each is linked with SINHCAF in more than 1 cancer types. Because this analysis shows association rather than direction, both SINHCAF-to-partner and partner-to-SINHCAF results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HMHB1 grouped by SINHCAF-low versus SINHCAF-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SINHCAF→partner) and Y-score (partner→SINHCAF) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	HMHB1 →	+0.087	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	CCL13 →	+0.046	+5.662	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 2 strongest of 2 associations by consensus.

HMHB1 by SINHCAF expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →