SIM2

Across TCGA cell cohorts, SIM2 RNA expression is significantly associated with the RNA expression of many other genes, with 6,418 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIM2-associated genes across cancer lineages are HLCS, AGPAT3, and FRMD3. Each is linked with SIM2 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIM2-to-partner and partner-to-SIM2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIM2 versus HLCS in LUNG_NSCLC_LUSC, with a Pearson correlation of 0.62.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIM2→partner) and Y-score (partner→SIM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	HLCS →	+1.107	+1.894	<.001	.001	2	6
OVARY	AGPAT3 →	+1.148	+1.320	.001	.001	3	4
URINARY_TRACT	FRMD3 →	+1.990	+1.397	<.001	<.001	3	4
URINARY_TRACT	ZNF543 →	+0.828	+1.527	<.001	<.001	3	4
SOFT_TISSUE	ANTXR1 →	+2.322	+1.880	<.001	.001	3	4
BONE	TSNARE1 →	+1.598	+3.336	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,418 associations by consensus.

SIM2 vs HLCS — LUNG_NSCLC_LUSC

Explore this scatter interactively →