SIK3

Across TCGA patient cohorts, SIK3 protein abundance is significantly associated with the protein abundance of many other proteins, with 20,222 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible SIK3-associated proteins across cancer lineages are DHX9, RBM39, and MSL1_S205. Each is linked with SIK3 in more than 5 cancer types. Because this analysis shows association rather than direction, both SIK3-to-partner and partner-to-SIK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, SIK3 versus DHX9 in LSCC, with a Pearson correlation of -0.56.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK3→partner) and Y-score (partner→SIK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	DHX9 →	-0.242	-0.244	<.001	<.001	3	6
LSCC	RBM39 →	-0.190	-0.208	<.001	<.001	3	5
BRCA	MSL1_S205 →	-0.729	-0.402	<.001	<.001	3	5
LUAD	SIK3_S551 →	+0.622	+0.194	<.001	<.001	2	6
PDAC	AAAS_S495 →	-1.898	-0.396	<.001	<.001	3	5
PDAC	CPSF6_T407 →	-0.754	-0.297	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 20,222 associations by consensus.

SIK3 vs DHX9 — LSCC

Explore this scatter interactively →