SIK3

Across TCGA patient cohorts, SIK3 mutation is significantly associated with the RNA expression of many other genes, with 3,355 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SIK3-associated genes across cancer lineages are RN7SL791P, KCTD9, and ATP1B2. Each is linked with SIK3 in more than 2 cancer types. Because this analysis shows association rather than direction, both SIK3-to-partner and partner-to-SIK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL791P grouped by SIK3-low versus SIK3-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK3→partner) and Y-score (partner→SIK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SL791P →	+0.081	+3.310	.002	.009	3	3
UCEC	KCTD9 →	+0.700	+2.332	<.001	<.001	3	3
UCEC	ATP1B2 →	-0.501	-1.796	.003	.003	3	3
UCEC	ZIC5 →	+0.569	+1.449	.001	.001	3	3
LUSC	SNORD116-18 →	+0.367	+3.525	<.001	<.001	3	3
UCEC	RNU6-1213P →	+0.087	+2.417	<.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,355 associations by consensus.

RN7SL791P by SIK3 expression — HNSC

Explore this box plot interactively →