SIK3

Across TCGA cell cohorts, SIK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,881 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SIK3-associated GO terms across cancer lineages are Positive regulation of TORC2 signaling, Regulation of alternative mRNA splicing, via spliceosome, and mRNA alternative polyadenylation. Each is linked with SIK3 in more than 16 cancer types. Because this analysis shows association rather than direction, both SIK3-to-partner and partner-to-SIK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of TORC2 signaling grouped by SIK3-low versus SIK3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SIK3→partner) and Y-score (partner→SIK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Positive regulation of TORC2 signaling →	+0.150	+0.875	<.001	.005	3	17
LUNG_SCLC	Regulation of alternative mRNA splicing, via spliceosome →	+0.099	+0.635	.001	.003	3	15
LARGE_INTESTINE	mRNA alternative polyadenylation →	+0.096	+1.034	<.001	<.001	3	13
STOMACH	Regulation of TORC2 signaling →	+0.182	+1.192	<.001	<.001	3	13
BONE	Pre-mRNA catabolic process →	+0.181	+0.768	<.001	.001	3	13
LUNG_SCLC	Regulatory ncRNA-mediated gene silencing →	+0.092	+0.656	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,881 associations by consensus.

Positive regulation of TORC2 signaling by SIK3 expression — LIVER

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