SIK3-IT1

Across TCGA pan-cancer cohorts, SIK3-IT1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated SIK3-IT1 data layer.

The strongest signal is observed in kidney chromophobe (KICH), where higher SIK3-IT1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated SIK3-IT1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and BRCA show a favorable association.

KICH, HNSC, and BLCA are the cancer types where SIK3-IT1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	DFS	Tertile	III,IV	0.173	0.913	<.001	74	view →
HNSC	OS	Tertile	III,IV	0.861	0.679	<.001	64	view →
BLCA	DFS	Tertile	All	0.202	0.482	.008	50	view →
ACC	OS	Median	IV	0.333	0.816	.004	34	view →
BRCA	OS	Median	III,IV	0.669	0.422	.007	28	view →
UVM	DFS	Median	III,IV	0.208	0.740	.006	16	view →
LIHC	OS	Tertile	II,III,IV	0.892	0.634	.010	14	view →
GBM	DFS	Tertile	All	0.334	0.198	.004	13	view →
LUSC	DFS	Median	IV	0.134	0.827	.014	12	view →
UCEC	OS	Quartile	II,III,IV	0.751	0.901	.014	10	view →
CHOL	OS	Quartile	All	0.212	0.868	.004	9	view →
ESCA	OS	Median	II,III,IV	0.625	0.768	.020	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

SIK3-IT1–KICH (DFS)

Open the KICH breakdown →