SIK3-IT1

Across TCGA pan-cancer cohorts, SIK3-IT1 RNA differs between tumor and matched normal tissue in 9 of 18 cancer types tested, making tumor–normal expression one of SIK3-IT1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SIK3-IT1 RNA is repressed in tumor relative to normal tissue. In most cancer types SIK3-IT1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, KICH, and BRCA are the cancer types where SIK3-IT1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SIK3-IT1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	All	−0.139	<.001	5	view →
KICH	Male	All	−0.124	<.001	5	view →
BRCA	All	III,IV	−0.320	<.001	2	view →
CHOL	All	II,III,IV	+0.159	.001	2	view →
LUAD	All	III,IV	−0.128	.028	2	view →
READ	All	All	−0.087	.028	2	view →
KIRP	Male	All	−0.097	.009	1	view →
LUSC	All	All	−0.078	.027	1	view →
HNSC	All	All	+0.023	.034	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 9 strongest of 9 lineages.

SIK3-IT1–THCA

Open the THCA breakdown →